Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

Journal of Chemical Biology

Hande Karaköse¹  Marius Matei¹  Sagar Deshpande¹  Hany Nour¹  Rakesh Jaiswal¹  Nikolai Kuhnert¹  Farnoosh Dairpoosh¹  Agnieszka Golon¹  Nadim Hourani¹ 

[1] School of Engineering and Science, Centre for Nano- and functional materials, Jacobs University Bremen, Campus Ring 8, 28759 Bremen, Germany

关键词: Polyphenols;    Enzyme inhibition;    Human diet;   

DOI  :  10.1007/s12154-011-0055-9

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose–response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.

【 授权许可】

Unknown