Association of GLUT4 gene variants with HbA1c level in Japanese men

Endocrine Journal

Koichi Miyaki¹  Yixuan Song²  Shinobu Ikeda¹  Chen Xi¹  Masaaki Muramatsu¹  Takuro Sinbo² 

[1] Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;Division of Clinical Epidemiology, Department of Clinical Research and Informatics, National Center for Global Health and Medicine, Tokyo 162-8655, Japan

关键词: Diabetes;    Glycemic control;    SLC2A4;    SNP;    Haplotype;   

DOI  :  10.1507/endocrj.EJ11-0409

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(23)Cited-By(3)GLUT4 is a major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis.Recent studies in south Indian populations revealed that haplotypes of the GLUT4 gene associated with type 2 diabetes.A total of 734 middle aged apparently healthy Japanese men were recruited from two separate occupational cohorts from Kanagawa and Kyoto.Participants were genotyped for GLUT4 variants, rs5418 (A/G) and rs2654185 (C/A), and association with HbA1c level was analyzed.The HbA1c value was determined by JDS method which is 0.4% lower than NGSP value.The G allele carrier of rs5418 and A allele carrier of rs2654185 associated with significantly higher HbA1c level (AG + GG vs. AA carriers; 5.2 ± 0.8 vs. 4.9 ± 0.4, P vs. CC; 5.2 ± 0.9, vs. 4.9 ± 0.4, P P = 0.026; β = 0.215, P = 0.026; β = 0.190, P = 0.042; β = 0.190, P = 0.042, respectively).These two SNPs are in high linkage disequilibrium (LD) of r2 = 0.67.In haplotype analysis, four haplotypes were estimated.HbA1c is significantly higher in the most frequent GA haplotype compared with the second frequent AC haplotype (5.2% vs. 5.1%, P = 0.004).Genetic variations, rs5418 and rs2654185 in GLUT4 gene are associated with HbA1c level in Japanese men.

【 授权许可】

Unknown