Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -

Endocrine Journal

Daisuke Katoh²  Yoshihiko Saito¹  Michihiro Yoshimura³  Hitoshi Nakagawa²  Yoshinobu Morikawa²  Eisaku Harada²  Yuji Mizuno²  Hirofumi Yasue²  Yusuke Kashiwagi² 

[1] First Department of Internal Medicine, Nara Medical University, Nara 634-8521, Japan;Division of Cardiovascular Medicine, Kumamoto Aging Research Institute / Kumamoto Kinoh Hospital, Kumamoto 860-8518, Japan;Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan

关键词: B-type natriuretic peptide;    Insulin resistance;    Free fatty acids;    Obesity;   

DOI  :  10.1507/endocrj.EJ12-0239

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(46)Cited-By(11)B-type natriuretic peptide (BNP) is produced by the heart and its plasma level is increased with the severity of left ventricular (LV) dysfunction/hypertrophy.The normal heart preferentially utilizes fatty acids as energy substrates.Plasma BNP levels are reported to be lower in obese individuals.We examined the relationship between BNP production and plasma free fatty acids (FFA), homeostasis model assessment of insulin resistance (HOMA-IR), and LV dysfunction/ hypertrophy.We examined the plasma BNP levels and FFA at the aortic root (AO) and coronary sinus (CS) as well as hemodynamic parameters in 62 patients (38 men and 24 women, 62.5±11.7 yrs) who underwent cardiac catheterization.Log BNP (AO) had a significant positive correlation with log BNP (CS-AO) (r=0.877, PPPPPPP=0.001).The multivariable regression analyses including log HOMA-IR, LVMI, and age as an independent variable revealed that HOMA-IR and LVMI were significant predictors of log BNP (CS-AO) or BNP production (P=0.001 and 0.004, respectively).We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals.

【 授权许可】

Unknown