Blood free fatty acids were not increased in high-fat diet induced obese insulin-resistant animals

卷:10

Jiang, Junfeng ; Wu, Yongjie ; Wang, Xiaoxia ; Lu, Li ; Wang, Li ; Zhang, Baolai ; Cui, Mingxia

Lanzhou Univ

关键词: Insulin resistance;    Free fatty acids;    Obesity;    Ciliary neurotrophic factor;    Sibutramine;   

DOI  :  10.1016/j.orcp.2015.06.005

学科分类：食品科学和技术

【 摘 要 】

Objective: The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals. Methods: Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs. Results: The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment. Conclusion: The results suggest that blood FFA are unlikely the link between obesity and insulin resistance. (C) 2015 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.