c-Kit Proto-oncogene Is More Likely to Lose Expression in Differentiated Thyroid Carcinoma Than Three Thyroid-specific Genes

Endocrine Journal

SHIRO NOGUCHI¹  IKUO YAMAMOTO³  FUJIO SAKAMOTO²  TETSUJI TANAKA³  TOMIO KOTANI³  KAZUMI UMEKI³  SACHIYA OHTAKI³ 

[1] Noguchi Thyroid Clinic & Hospital Foundation;Department of Neurology, Minami-Kyushu Rehabilitation Hospital;Department of Laboratory Medicine, Miyazaki Medical College

关键词: c-kit;    Differentiated thyroid carcinoma;    Papillary carcinoma;    Follicular carcinoma;    Thyroid differentiation;   

DOI  :  10.1507/endocrj.42.723

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(6)Although c-kit proto-oncogene product is known to be weakly expressed on normal thyrocytes, its function is unclear. In order to investigate the significance of thyroid c-kit, c-kit gene expression in 37 various thyroid tissues was analyzed by comparing c-kit gene expression with the mRNA expression of three thyroid-specific genes: thyroid peroxidase, thyroglobulin, and thyroid stimulating hormone receptor. c-kit mRNA was hardly detected by the usual northern blot method in 2 of 7 follicular carcinomas, 11 of 12 papillary carcinomas, and a medullary carcinoma. On the other hand, a high level of c-kit mRNA expression was found in all 17 benign thyroid tissues (4 normal thyroid tissues, 4 Graves' disease, 2 adenomatous goiters, and 7 follicular adenomas). This study found that c-kit proto-oncogene is more likely to lose expression in differentiated thyroid carcinoma than any thyroid-specific gene. Decreased c-kit gene expression may serve as an indicator for the de-differentiation of thyrocytes.

【 授权许可】

Unknown