Synchronous Occurrence of a Follicular, Papillary and Medullary Thyroid Carcinoma in a Recurrent Goiter

Endocrine Journal

U. RAMP¹  A. RAFFEL²  A. WOLF²  M. KRAUSCH²  Kenko CUPISTI²  W.T. KNOEFEL²  A. DONNER¹  C.F. EISENBERGER² 

[1] Institute of Pathology, Heinrich-Heine University;Department of General and Visceral Surgery, Heinrich-Heine University

关键词: Papillary carcinoma;    Follicular carcinoma;    Medullary carcinoma;   

DOI  :  10.1507/endocrj.52.281

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(9)The simultaneous occurrence of different types of thyroid carcinoma in a single patient is an unusual event. We report the case of a 52-year-old man with the history of two previous thyroid operations for benign goiters, who developed a recurrent goiter. The patient was referred to our department for thyroidectomy. In the pathohistological examination the specimen showed a 5 cm follicular carcinoma and a 0.3 cm papillary microcarcinoma in the right lobe as well as a 1.5 cm medullary carcinoma in the left lobe. All tumors were clearly separated from each other, representing the pure entity of each type. Postoperatively, RET germline mutation was ruled out by sequence analysis of peripheral blood leucocytes. Postoperative I-131-radioiodine scan showed multiple lung and liver metastases, while calcitonin was negative. There is no known common cause of these three different tumor types and they developed most independently from each other. The personal history of our patient was interesting in two aspects: (1) he suffered a period of severe staphylococcal sepsis with temporal immunosuppression and (2) he worked for long years as a coremaker in a foundry. This work represented possible long term exposure to inhalative carcinogenous toxins like hydrazine, which caused thyroid parafollicular cell adenomas in an animal model.

【 授权许可】

Unknown