Endocrine Journal | |
Quantitative Analysis of Osteonectin mRNA in Thyroid Carcinomas | |
KANJI KUMA3  HIROSHI YOSHIDA3  NOBUYASU HAYASHI1  AKIRA MIYAUCHI3  YUKIKO HASEGAWA2  SHOJI NAKAMORI1  FUMIO MATSUZUKA3  NOBUYUKI AMINO2  TORU TAKANO2  | |
[1] Department of Surgery and Clinical Oncology, Osaka University Medical School;Department of Laboratory Medicine, Osaka University Medical School;Kuma Hospital | |
关键词: Thyroid carcinoma; Reverse transcription-PCR; Fine needle aspiration biopsy; Osteonectin; | |
DOI : 10.1507/endocrj.49.511 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
References(30)Cited-By(10)Our recent study of the gene expression profile in thyroid carcinoma showed an overexpression of osteonectin mRNA, an extracellular matrix protein, in an anaplastic carcinoma. To confirm this, we measured the expression levels of osteonectin mRNA in 84 thyroid normal and tumor tissues, including five anaplastic carcinomas by realtime quantitative reverse-transcription PCR. Increased expression of osteonectin mRNA was observed in anaplastic carcinoma tissue. However, in five anaplastic carcinoma cell lines, no increase was observed in the expression levels of osteonectin mRNA. These findings suggest the possibility that increased expression of osteonectin mRNA in anaplastic carcinoma tissue may be due to its overexpression in stromal cells, but not in anaplastic carcinoma cells.
【 授权许可】
Unknown
【 预 览 】
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RO201911300720161ZK.pdf | 409KB | download |