The Higher Immunoreactivity to ACE (Angiotensin Converting Enzyme) in Patients with Type 2 Diabetes Mellitus than in Non-Diabetic Individuals

Endocrine Journal

YASUSHI HIROKAWA⁴  MICHIHIRO MATSUKI⁴  TSUTOMU NOHNO²  SEIKOH NISHIDA⁴  JUNJI TANAKA¹  KIYOSHI ICHIHARA³ 

[1] Division of Cardiology, Department of Medicine, Kawasaki Medical School;Department of Molecular Biology, Kawasaki Medical School;Department of Clinical Pathology, Kawasaki Medical School;Division of Endocrinology, Department of Medicine, Kawasaki Medical School

关键词: Immunoreactivity to ACE;    ELISA assay;    Type 2 diabetes mellitus;    Diabetic nephropathy;   

DOI  :  10.1507/endocrj.50.209

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(7)Cited-By(3)In a random sample of 200 patients with type 2 diabetes mellitus, immunoreactivities to ACE (angiotensin converting enzyme) were measured by ELISA. Immunoreactivities were positive for 129 (64.5%) patients, and were positive in 30 (83.3%) out of 36 patients in the early stage of clinical diabetic nephropathy. Serum ACE activity in rabbits immunized with ACE decreased to 50% of the control level after 7 months (78.0±3.8 IU/L/37°C, basal, 42.0±5.0 at 7 months and 33.3±3.5 IU/L/37°C at 8 months, respectively). When rabbit serum containing antiACE antibodies was mixed, after heat-treatment at 56°C for 30 min, with normal human serum, the ACE activity was reduced in a concentration-dependent manner. These results suggested that anti-ACE autoantibody may be present in patients with type 2 diabetes mellitus. However, the absence of data on the epitope for the antibody does not allow any conclusion except that the immunoreactivities to ACE are higher in type 2 diabetic patients than in non-diabetic individuals.

【 授权许可】

Unknown