Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxinein male Shiba goats

Journal of Veterinary Medical Science

Kazuaki SASAKI²  Takara SAKIYAMA²  Rania ABOHATAB¹  Mohamed ELBADAWY²  Minoru SHIMODA² 

[1] Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183�?8509, Japan

关键词: diclofenac;    flip-flop phenomena;    goat;    oral pharmacokinetic;    sulfamonomethoxine;   

DOI  :  10.1292/jvms.14-0261

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Cited-By(3)In the present study, weexamined the oral pharmacokinetics of the acidic drugs, diclofenac (DF) andsulfamonomethoxine (SMM), which have different physicochemical properties, in Shiba goats.DF and SMM were intravenously and orally administered to 5 male goats using a crossoverdesign. The Tmax of DF and SMM were reached 1.5 and 5.6 hr after they have beenorally administered, respectively, and this was followed by their slow elimination. Theelimination of both drugs was markedly faster after being intravenously rather than orallyadministered, which indicated flip-flop phenomena after the oral administration. The meanabsorption times (MATs) of DF and SMM were 6 and 15 hr, respectively. This slow absorptionmay have been due to slow gastric emptying in goats. The large difference observed in MATsbetween DF and SMM may have been because DF, which is more lipophilic than SMM, was partlyabsorbed from the forestomach. Therefore, these results suggest that the absorption ofhighly lipophilic drugs from the forestomach may be markedly high in Shiba goats. In caseof drugs whose elimination is quite fast, their efficacies may appear from the early stageafter oral administration even in ruminants, because elimination rate is the determinantfactor of Tmax in flip-flop phenomena. Such drugs may be used orally even inruminants.

【 授权许可】

Unknown