Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations

Sensors

Dana Vlascici²  Stela Pruneanu⁴  Liliana Olenic⁴  Florina Pogacean⁴  Vasile Ostafe²  Vlad Chiriac²  Elena Maria Pica³  Liviu Calin Bolundut³  Luminita Nica¹ 

[1] Victor Babes University of Medicine and Pharmacy Timisoara, Revolutiei Ave. No. 9, Timisoara, Romania; E-Mail:;West University of Timisoara, 4 V. Parvan Ave, Timisoara 300223 Timis, Romania; E-Mails:;Technical University of Cluj-Napoca, Faculty of Science and Materials Engineering, 28 Memorandumului Street, 400114, Cluj-Napoca, Romania; E-Mails:;National Institute of Research and Development for Isotopic and Molecular Technologies, 65-103 Donath Street 400293, Cluj-Napoca, Romania; E-Mails:

关键词: diclofenac;    manganese porphyrins;    ion–selective electrodes;    potentiometry;    electrochemical impedance spectroscopy;    pharmaceuticals;   

DOI  :  10.3390/s101008850

来源: mdpi

【 摘 要 】

Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac–selective electrodes. The electroactive material was incorporated either in PVC or a sol–gel matrix. The effect of different plasticizers and additives (anionic and cationic) on the potentiometric response was studied. The best results were obtained for the PVC membrane plasticized with dioctylphtalate and having sodium tetraphenylborate as a lipophilic anionic additive incorporated. The sensor response was linear in the concentration range 3 × 10⁻⁶ – 1 × 10⁻² M with a slope of −59.7 mV/dec diclofenac, a detection limit of 1.5 × 10⁻⁶ M and very good selectivity coefficients. It was used for the determination of diclofenac in pharmaceutical preparations, by direct potentiometry. The results were compared with those obtained by the HPLC reference method and a good agreement was found between the two methods.

【 授权许可】

CC BY   
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