Immune Response and Pasteurella Resistance in Rabbits Fed Diets Containing Various Amounts of Black Cumin Seeds | Science Publications

American Journal of Animal and Veterinary Sciences

Safia M. B. Elhag¹  Anton C. Beynen¹  Imtithal T.O. Farah¹  Ahmed Alhaidary¹  Hasab E. Mohamed¹  Nabiela M. El Bagir¹  Nabiela M.E. Bagir¹  Safia M.B. Elhag¹  Imtitha T. O. Farah¹ 

关键词: Rabbits;    antibody production;    phagocytosis;    hypersensitivity;    Pasteurellosis;    black cumin;   

DOI  :  10.3844/ajavsp.2010.163.167

学科分类：兽医学

来源: Science Publications

【 摘 要 】

Problem statement: The consumption of black cumin (Nigella sativa) seed has immunomodulatory and anti-bacterial activity, but in rabbits this had not yet been tested. Approach:In the present studies, rabbits were fed diets without or with black cumin seed and antibody production, phagocytotic activity, hypersensitivity and resistance against Pasteurellosis were assessed. Results: Feeding black cumin seed significantly increased serum concentrations of antibodies in response to intramusculary injected serum bovine albumin. Blood derived from rabbits fed the diets containing either 15 or 20% black cumin seed significantly reduced the growth of Staphylococcus aureus on sheep-blood agar plates. Skin thickness as index of hypersensitivity towards tuberculin was significantly reduced at 48 h after intradermal injection of the agent. Ingestion of black cumin seed significantly extended survival time after intraperitoneal administration of Pasteurella multocida. Conclusion: The feeding of black cumin seed to rabbits stimulated their immune system, but did not enhance inflammation.

【 授权许可】

Unknown