Saccharomyces uvarum mannoproteins stimulate a humoral immune response in mice

Brazilian Archives of Biology and Technology

Fernanda Patrícia Brito Darpossolo¹  Silas Fernandes Eto¹  Emerson José Venancio¹  Raul Jorge Hernan Castro-goméz¹ 

[1] ,Universidade Estadual de LondrinaLondrina PR ,Brasil

关键词: glycoprotein;    Swiss mice;    antibody production;    yeast;    cell wall;   

DOI  :  10.1590/S1516-89132012000400016

来源: SciELO

【 摘 要 】

Yeasts discarded in industrial processes can be used as a nutritional supplement and to extract cellular components with biotechnological aims. In this study, the humoral immune response of Swiss mice treated with mannoproteins (MP) from the yeast Saccharomyces uvarum was evaluated. The mice were treated with MPs at different doses and times and inoculated with 2% sheep red blood cells. An increase in total Ig in mice treated with 100 μg of MP at the time of immunization or 24 h before was observed in the primary immune response; in the secondary immune response, an increase was observed in total Ig values for all groups, and an increase of IgG was observed in the mice treated with MPs (100 μg) at the time of immunization or 24 h before. These results show that S. uvarum MPs present an immunostimulatory action on the humoral immune response in mice.

【 授权许可】

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