Serum Concentrations of Granulocyte Colony-Stimulating Factor (G-CSF) in Antithyroid Drug-Induced Agranulocytosis

Endocrine Journal

Tetsuya HIRAIWA⁴  Akira MIYAUCHI¹  Toshiaki HANAFUSA⁴  Mitsuru ITO⁴  Nakaaki OHSAWA⁶  Yasuhiro MURAKAMI⁵  Sadaki SAKANE³  Junta TAKAMATSU²  Ichiro SASAKI⁴  Takeshi ARISHIMA⁴  Kanji KUMA¹ 

[1] The Kuma Hospital;Takamatsu Thyroid Clinic;Department of Medicine, Hirakata City Hospital;First Department of Internal Medicine, Osaka Medical College;Comprehensive Medical Center for Health, Otemae Hospital;Aino Institute for Aging Research

关键词: Granulocyte colony-stimulating factor (G-CSF);    Chemiluminescent enzyme immunoassay;    Methimazole induced-agranulocytosis;   

DOI  :  10.1507/endocrj.51.579

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(3)Granulocyte colony-stimulating factor (G-CSF) levels in serum were determined by a highly-sensitive chemiluminescent enzyme immunoassay (limit of detection, 0.5 pg/ml) in 54 patients with Graves' disease including 6 patients complicated with methimazole-induced agranulocytosis. Serum G-CSF levels in patients with Graves' disease were not different from normal subjects and did not correlate with serum FT4 level or circulating neutrophil counts. Before the onset of agranulocytosis, there was no difference in serum G-CSF level between the patients complicated with agranulocytosis and the uncomplicated patients. When circulating neutrophil counts decreased to less than 0.5 × 109/L, serum G-CSF level elevated with the mean of 106.8 ± 82.2 (SD) pg/ml, but the level did not correlate with the duration of agranulocytosis. Interestingly, maximum serum G-CSF level during the treatment with recombinant human G-CSF (100 μg/day) was related to bone marrow finding at the onset of agranulocytosis and correlated with the duration of agranulocytosis (r = 0.824, p<0.05). In conclusion, measuring serum G-CSF levels with a highly-sensitive chemiluminescent enzyme immunoassay revealed that 1) thyrotoxicosis does not affect serum G-CSF level, 2) serum G-CSF level during antithyroid drug treatment does not play an important role in development of agranulocytosis, 3) the maximum serum G-CSF level in the course of agranulocytosis is related to the responsiveness of bone marrow to G-CSF and the recovery time from agranulocytosis.

【 授权许可】

Unknown