Increased Serum Human Granulocyte Colony-Stimulating Factor (G-CSF) Levels Following Intravenous Infusion of High-Dose Methyiprednisolone

Endocrine Journal

TOSHIO WAKAYAMA¹  YOSHIO MURAKAMI¹  MOTOI SOHMIYA¹  HIROSHI FURUYA¹  YUZURU KATO¹ 

[1] First Division, Department of Medicine, Shimane Medical University

关键词: Granulocyte colony-stimulating factor (G-CSF);    ETA;    Methylprednisolone;    Neutrophil count;   

DOI  :  10.1507/endocrj.43.67

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(6)Serum granulocyte colony-stimulating factor (G-CSF) levels were measured for 24h in 6 patients with hematological disorders and two patients with Graves' disease associated with malignant exophthalmos after iv infusion of high-dose methylprednisolone (HDMP) (20mg/kg BW)for 2h starting at 0900h. Saline solution (500ml) was infused iv for 2h as a control on two days before starting the HDMP therapy. Serum G-CSF levels increased with the mean peak values at 4h after the HDMP therapy (mean±SD: 488.1±125.8pg/ml vs. saline control 74.4±21.9pg/ml, P<0.01). Circulating absolute neutrophil counts (ANC) also increased with the mean peak values at 24h after the HDMP (6, 057±1, 460/μl vs. saline control 2, 007±390/μl, P<0.025). These findings indicate that glucocorticoid has a stimulating effect on G-CSF release and that the increased G-CSF release could be involved, at least partly, in neutrophilia induced by glucocorticoid.

【 授权许可】

Unknown