Immunosuppression Induced by a Conditioned Stimulus Associated With Cocaine Self-Administration

Journal of Pharmacological Sciences

Monika Leskiewicz²  Agnieszka Basta-Kaim²  Lucylla Jaworska-Feil²  Marta Kubera²  Edmund Przegalinski¹  Malgorzata Filip¹  Karolina Wydra¹  Anna Machowska³  Wladyslaw Lason²  Boguslawa Budziszewska²  Magdalena Regulska² 

[1] Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Poland;Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Poland;Collegium Medicum, Jagiellonian University, Poland

关键词: cocaine;    extinction;    relapse;    self-administration;    immune system;   

DOI  :  10.1254/jphs.FP0072106

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(44)Cited-By(11)Cocaine addiction is known to impair immune system function, but the effects of repeated treatment with cocaine in a self-administration model, its withdrawal as well as reinstatement of cocaine-seeking behavior on cell-mediated immunity are not well known. Cocaine self-administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10, and tumor necrosis factor-α production, while concanavalin A–stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-γ production by splenic lymphocytes were not altered. After 10 days withdrawal from cocaine, reinstatement of cocaine seeking behavior induced either by a priming dose of the drug (unconditioned stimulus), by cue previously associated with cocaine self-administration (conditioned stimuli), or by both these stimuli evoked similar changes in several immunological parameters, for example, a decrease in relative spleen weight, proliferative activity of splenocytes, and their ability to produce IL-10. The results showed that the cue previously associated with cocaine suppressed some parameters of cell-mediated immunity to the same degree as re-exposure to cocaine. The present study provides the first evidence that alterations of immune status can be conditioned by environmental stimuli paired with cocaine administration.

【 授权许可】

Unknown