Incubation of sucrose craving: effects of reduced training and sucrose pre-loading

PHYSIOLOGY & BEHAVIOR

卷:84

Article

Grimm, JW ; Fyall, AM ; Osincup, DP

关键词: cocaine;    craving;    cue-induced;    eating disorder;    extinction;    incubation;    rat;    reinstatement;    relapse;    sucrose;    time-dependent;   

DOI  :  10.1016/j.physbeh.2004.10.011

来源: Elsevier

【 摘 要 】

Time-dependent increases in cue-induced reward seeking after forced abstinence were described in rats with a history of cocaine or sucrose self-administration, suggesting reward craving incubates over time. In the present study, we examined the effects of reduced training experience, or sucrose pre-loading just prior to testing, on the incubation of sucrose craving. Sucrose seeking (responding in extinction and then for a sucrose-paired cue) increased over time in groups of rats that self-administered sucrose 6 h/day for 10 days and were tested at 1, 7, or 30 days of forced abstinence. We found that groups of rats that had self-administered 2 instead of 6 h/day showed a similar profile of responding. Incubation of sucrose craving was attenuated by free access to sucrose in home cages for 17 h immediately prior to testing assessed as extinction responding on days 1 and 30. However, this sucrose pre-loading had no effect on the time-dependent increase in responding for the sucrose-paired cue. In summary, reducing the training experience had no effect on the incubation of sucrose craving and free access to sucrose had only a limited effect-attenuating extinction responding. These results illustrate the strength of the incubation of craving and further suggest long-term changes in brain motivational circuitry following sucrose self-administration. (C) 2004 Elsevier Inc. All rights reserved.

【 授权许可】

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