Interleukin-18 induces insulin resistance in the hyperthyroid state

Endocrine Journal

Shin Yamamoto³  Shinya Furukawa³  Yoichi Hiasa³  Teruki Miyake³  Masaaki Tamaru⁴  Tohru Eguchi²  Masanori Abe³  Teruhisa Ueda³  Shozo Miyauchi²  Bunzo Matsuura¹  Morikazu Onji³ 

[1] Department of Lifestyle-related Medicine, Ehime University Graduate School of Medicine, Toon 791-0295, Japan;Department of Internal Medicine, Uwajima City Hospital, Uwajima 798-8510, Japan;Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan;Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari 799-1592, Japan

关键词: Graves’ disease;    Hyperthyroidism;    Interleukin-18;    Insulin resistance;    HOMA-R;   

DOI  :  10.1507/endocrj.EJ12-0136

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)We previously reported that serum interleukin-18 (IL-18) levels were significantly increased in hyperthyroid Graves’ disease patients.The development of insulin resistance in hyperthyroidism has been documented. We investigated the relationship between IL-18 and insulin resistance in patients with hyperthyroid Graves’ disease and in experimental hyperthyroid mice.Then, we examined whether IL-18 induces insulin resistance in mice injected with IL-18 for a week.A significant positive correlation was observed between serum IL-18 levels and parameters such as thyroid functions and homeostasis model assessment for insulin resistance in hyperthyroid Graves’ disease.In experimental hyperthyroid mice, IL-18 was significantly elevated.Insulin resistance increased in experimental hyperthyroid mice and IL-18-injected mice.These findings suggest IL-18 to be an important factor inducing insulin resistance in hyperthyroidism.

【 授权许可】

Unknown