Prediction of late (24-hour) radioactive iodine uptake using early (3-hour) uptake values in Japanese patients with Graves’ disease

Endocrine Journal

Masahiro Hata¹  Zenei Arihara¹  Kanako Sakurai¹  Hiroshi Fukazawa¹  Yoshinori Osaki¹ 

[1] Department of Endocrinology and Metabolism, Federation of National Public Service and Affiliated Personnel Mutual Aid Associations, Suifu Hospital, Mito 311-4141, Japan

关键词: Graves’ disease;    Hyperthyroidism;    123I-Radioactive iodine uptake;    Radioiodine therapy;    Japanese;   

DOI  :  10.1507/endocrj.EJ11-0279

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(11)Cited-By(2)Measurement of 24-hour radioactive iodine uptake (RAIU), which is commonly used to calculate the dose of radioiodine (RI) therapy, cannot be accomplished in a single day.The purpose of this study was to predict 24-hour RAIU from 3-hour RAIU in Japanese patients with Graves’ disease, and to investigate other factors that could be used to predict 24-hour RAIU.A total of 66 Japanese patients (14 men and 52 women; age, 17-83 years) with Graves’ disease who had undergone both 3-hour and 24-hour 123I RAIU measurements between January 2006 and September 2011 were included in this study.Stepwise multiple regression analyses were performed in order to identify factors that could be used to predict 24-hour RAIU.The investigated factors were gender, age, thyroid volume, TSH, free thyroxine (FT4), free triiodothyronine (FT3), serum creatinine, second generation assay TSH receptor antibody (TRAb2), antithyroid drugs discontinuation period (ADP), iodine restriction period and 3-hour RAIU.The ADP was converted to an ordinal scale ADP score (ADPS) for multiple regression analyses.Multiple regression analyses showed that 3-hour RAIU (P P P 10 EU + 23.0 × log10 FT3 - 2.7 × ADPS (r = 0.82, P < 0.001).The present results indicate that prediction of LU from EU, FT3 and ADPS is feasible in Japanese patients with Graves’ disease.

【 授权许可】

Unknown