Serum free thyroxine levels are associated with the efficacy of weight reduction therapy in obese female patients

Endocrine Journal

Hajime Yamakage²  Noriko Satoh-Asahara²  Yoshihiro Ogawa³  Kazuya Muranaka²  Shigeo Kono²  Tetsuya Tagami¹  Masashi Tanaka²  Shinji Odori²  Koshi Hashimoto⁴  Akira Shimatsu¹ 

[1] Division of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan;Division of Diabetic Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan;Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;Department of Preemptive Medicine and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan

关键词: Thyroid function;    Free thyroxine;    TSH;    Obesity;    Weight reduction therapy;   

DOI  :  10.1507/endocrj.EJ15-0498

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Thyroid function is strongly associated with obesity.The aim of this study is to investigate whether serum free thyroxine (FT4) and/or thyrotropin (TSH) levels are associated with the efficacy of weight reduction therapy in obese patients.We enrolled a total of 283 obese patients and cross-sectionally investigated the association of serum FT4 and/or TSH levels with metabolic features.Furthermore, in 97 obese patients who received 6-month weight reduction therapy, we assessed the relationship of serum FT4 and/or TSH levels to the efficacy of weight reduction therapy.Neither baseline serum FT4 nor TSH levels showed any correlations with body weight (BW) and body mass index (BMI) in these obese patients.However, in 57 obese female patients who underwent weight reduction therapy for six months, serum FT4 levels prior to the therapy was negatively correlated with the degrees of reduction of BW (r = -0.354, p = 0.007) and BMI (r = -0.373, p = 0.004).The correlation between baseline serum FT4 levels with the efficacy of weight reduction therapy was not observed in obese male or postmenopausal female patients.This study demonstrates that baseline serum FT4 levels are associated with weight reduction in obese female premenopausal patients.Therefore, baseline FT4 levels can be used as a clinical, noninvasive, hormonal predictor of weight reduction efficacy in obese patients.

【 授权许可】

Unknown