Thyrotoxicosis with absence of clinical features of acromegaly in a TSH- and GH-secreting, invasive pituitary macroadenoma

Endocrinology, Diabetes & Metabolism Case Reports

article

Philip C Johnston¹  Amir H Hamrahian¹  Richard A Prayson²  Laurence Kennedy¹  Robert J Weil² 

[1] Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation;Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic

关键词: Adult;    Female;    White;    United States;    Pituitary;    Pituitary;    TSH;    GH;    Pituitary adenoma;    Plurihormonal pituitary adenoma;    Hemianopia;    Hirsutism;    Palpitations;    Hot flushes;    Sweating;    Obesity;    MRI;    Thyroid function;    Total T4;    Total T3;    FT4;    TSH;    IGF1;    GH;    Prolactin;    Cortisol (serum);    ACTH stimulation;    Immunohistochemistry;    Transsphenoidal surgery;    Octreotide;    Methimazole;    Surgery;    Unique/unexpected symptoms or presentations of a disease;    January;    2015;   

DOI  :  10.1530/EDM-14-0070

学科分类：血液学

来源: Bioscientifica Ltd.

【 摘 要 】

A 54-year-old woman presented with bi-temporal hemianopia, palpitations, and diaphoresis. An invasive pituitarymacroadenoma was discovered. The patient had biochemical evidence of secondary hyperthyroidism and GH excess;however, she did not appear to be acromegalic. Surgical removal of the pituitary mass revealed a plurihormonal TSH/GHco-secreting pituitary adenoma. TSH-secreting adenomas can co-secrete other hormones including GH, prolactin, andgonadotropins; conversely, co-secretion of TSH from a pituitary adenoma in acromegaly is infrequent.

【 授权许可】

CC BY-NC-ND