Sensitivity for the Detection of a Clonally Rearranged Antigen Receptor Gene in Endoscopically Obtained Biopsy Specimens from Canine Alimentary Lymphoma

Journal of Veterinary Medical Science

Koichi OHNO¹  Hajime TSUJIMOTO¹  Yuko KOSHINO-GOTO¹  Kenjiro FUKUSHIMA¹  Masashi TAKAHASHI¹  Kazuyuki UCHIDA²  Ko NAKASHIMA¹  Yasuhito FUJINO¹  Kohji NOMURA³ 

[1] Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Marupi Lifetech Co., Ltd.

关键词: cancer diagnosis;    canine;    gastro-intestinal disease;    lymphoma/leukemia;    PCR;   

DOI  :  10.1292/jvms.001673

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(13)Canine alimentary lymphoma is currently diagnosed on the basis of findings of cytological or histopathological examination. However, it is often difficult to histopathologically distinguish alimentary lymphoma from lymphocytic-plasmacytic enteritis. Recently, the application of polymerase chain reaction for antigen receptor gene rearrangement (PARR) has been reported. In the present study, we assess the sensitivity of PARR analysis in diagnosing canine alimentary lymphoma using endoscopically obtained biopsy specimens from 12 dogs that were histopathologically diagnosed as having lymphoma. The sensitivity of PARR analysis in diagnosing alimentary lymphoma was found to be 66.7%, which was lower than that of other lymphoid malignancies. A combination of histipathological examination and findings of PARR analysis may improve the diagnostic accuracy.

【 授权许可】

Unknown