A Case of Canine Lymphomatoid Granulomatosis with Cutaneous Lesions

Journal of Veterinary Medical Science

Hajime TSUJIMOTO²  Yuko GOTO-KOSHINO²  Toru SHIMAZAKI¹  Kinji SHIROTA⁴  Masahiko NAGATA³ 

[1] Noya Animal Hospital;The University of Tokyo;Animal Dermatology Center;Azabu University

关键词: canine;    lymphoma/leukemia;    pathology;    PCR;    skin disease;   

DOI  :  10.1292/jvms.09-0479

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(2)A 10-year-old, castrated, mixed-breed dog presented with a 1.5-month history of scattered, crateriform ulcers on the trunk and extremities. Some skin lesions appeared to regress spontaneously, but new lesions developed. Thoracic radiography revealed pulmonary consolidated lesions suggestive of tumor. A skin biopsy was performed for histopathological, immunohistochemical and clonality analyses. Histopathological examination of the cutaneous lesion revealed an intense infiltration of atypical lymphoid cells with some other cell populations around the blood vessels in the dermis. Atypical lymphoid cells were shown to be CD3-positive in the immunohistochemical analysis. The presence of clonally expanded T-cells was revealed by the clonal rearrangement of T-cell receptor γ-chain gene. From the above findings, the dog was diagnosed with lymphomatoid granulomatosis.

【 授权许可】

Unknown