Decreasing Brain Natriuretic Peptide Levels after Treatment for Hyperthyroidism

Endocrine Journal

Oznur Sari URE²  Metin KUCUKAZMAN²  Naim ATA²  Derun Taner ERTUGRUL²  Emre TUTAL²  Beyza ALGUL²  Kursad DAL²  Ahmet Arif YALCIN⁴  Onur Sinan DEVECI⁴  Kadir Okhan AKIN³  Nihat CANBOLAT¹  Bunyamin YAVUZ⁴ 

[1] Iskenderun Millitary Hospital, Department of Cardiology, Ankara, Turkey;Kecioren Teaching and Research Hospital, Department of Internal Medicine, Ankara, Turkey;Kecioren Teaching and Research Hospital, Department of Biochemistry, Ankara, Turkey;Kecioren Teaching and Research Hospital, Department of Cardiology, Ankara, Turkey

关键词: Hyperthyroidism;    BNP;    Echocardiography;    Heart failure;   

DOI  :  10.1507/endocrj.K09E-159

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(1)BNP are produced in ventricular cardiomyocytes, and secreted in response to volume expansion or pressure overload. The purpose of this study was to assess BNP levels in patients with hyperthyroidism before specific treatment for hyperthyroidism and after euthyroidism was achieved. The study was performed in a prospective design. The study population consisted of 48 consecutive newly diagnosed untreated overt hyper-thyroid patients who had not been treated any anti-thyroid medications before. All subjects underwent transt-horacic echocardiography. Levels of fT3, fT4, TSH and BNP were measured before the onset of the treatment and after euthyroidism was achieved. A significant decrease in BNP (102.5 (6.7-1769) ng/L vs. 5.0 (0.1-87.0) ng/L p< 0.001) levels were observed, after euthyroidism was achieved. The decrease in BNP levels was posi-tively correlated with the decrease in fT3 (r=0.298; p=0.049) and fT4 (r=0.313; p=0.030). There was no cor-relation between BNP levels and TSH levels (p=NS). We conclude that hyperthyroidism may cause high BNP measurements which can lead to misdiagnosis of congestive heart failure. We suggest that thyroid hormones should be checked in patients with high levels of BNP.

【 授权许可】

Unknown