Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents

Revista Brasileira de Epidemiologia

Silva, Larissa R.¹  Pizzi, Juliana¹  Timossi, Luciana S.¹  Leite, Neiva¹  Stefanello, Joice M. F.¹ 

[1]Universidade Federal do Paraná

关键词: Atherosclerosis;    Obesity;    Ultrasonography;    Child;    C-reactive protein;    Adiponectin;    Meta-analysis;   

DOI  :  10.1590/S1415-790X2012000400012

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

We conducted a systematic review of intima-media thickness(IMT) and inflammatory markers, compared IMT and identified by meta-analysis related to EMI and inflammatory variables in obese and non-obese children and adolescents. We searched for articles in databases Pubmed, Bireme and Science Direct, during years 2000 and 2010, with the following key words in English: "obesity", "adolescents", "atherosclerosis" and "child ", They were used in two combinations: obesity + adolescents + atherosclerosis + child + obesity and atherosclerosis. We used meta-analysis to compare IMT between obese and non-obese patients. We carefully selected 16 articles for final analysis. There were differences in the thickness of IMT between obese and non-obese patients in 12 studies, confirmed by meta-analysis. Obese patients had concentrations of C-reactive protein higher in 13 articles analyzed (p < 0.05) and lower adiponectin levels in 4 (p < 0.05). In general, obese men had lower concentrations of adiponectin and higher values of IMT and C-reactive protein than non-obese men, showing the relationship between obesity and early inflammatory process. We concluded that there is a relationship of obesity with increased IMT and changes in concentrations of inflammatory markers in this phase.

【 授权许可】

CC BY