Brazilian Journal of Infectious Diseases | |
Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation | |
Lima, Bárbara Perdonsini1  Beloto, Nayara Carvalho Polido1  Sagrado, Andressa Gervasoni1  Raboni, Sonia Mara1  Demeneck, Henrique1  Oliveira, Andre1  Tuon, Felipe Francisco1  Franzoni, João Paulo1  Pedroso, Maria Lucia1  Largura, Denis1  | |
[1] Universidade Federal do Paraná, Curitiba, Brazil | |
关键词: Human immunodeficiency virus; Hepatitis B; Hepatitis C; Co-infection; | |
DOI : 10.1016/j.bjid.2014.05.011 | |
来源: Contexto | |
【 摘 要 】
Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Parana, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of patients, and the infection was confirmed in 72% of the cases. Eighteen patients (19%) were human immunodeficiency virus/hepatitis B virus positive (detectable HBsAg). Among co-infected patients, there was a high frequency of drug use, and investigations for the detection of co-infection were conducted late. A low number of patients were eligible for treatment and, although the response to antiretroviral therapy was good, there was a very poor response to hepatitis therapy. Our preliminary findings indicate the need for protocols aimed at systematic investigation of hepatitis B virus and hepatitis C virus in human immunodeficiency virus-infected patients, thus allowing for early detection and treatment of co-infected patients.
【 授权许可】
Unknown
【 预 览 】
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RO201911300560146ZK.pdf | 490KB | download |