A Case of Type 2 Diabetes Mellitus in an Elderly Patient with Rapid Attenuation of Insulin Secretion that Resembled Fulminant Type 1 DM but with Incomplete Beta Cell Damage

Endocrine Journal

Takayuki HOSOI¹  Atsushi ARAKI²  Yoshiaki TAMURA²  Yasuaki ISHIMARU³  Seijiro MORI²  Toshiyuki HORIUCHI²  Yasuyo ISHIMARU³  Yuko CHIBA² 

[1] Present Address: Department of Advanced Medicine, National Center of Geriatrics and Gerontology;Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital;Department of Internal Medicine, Ishimaru Hospital

关键词: Fulminant type 1 diabetes;    Type 2 diabetes;    Elderly;   

DOI  :  10.1507/endocrj.K06-008

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(3)We recently encountered a 66-year-old Japanese man who had suffered from acute hyperglycemia following flu-like symptoms during treatment of type 2 diabetes. Despite significantly increased plasma glucose levels, HbA1c was only slightly elevated. The possibility of autoimmune type 1 diabetes was excluded because of negative islet-related autoantibodies. Serum levels of pancreatic exocrine enzymes, amylase, lipase, and elastase-l were elevated. However, the insulin-secreting function of his islets was not severely damaged. This case is particularly notable for two reasons. First, it showed a fulminant type 1 diabetes-like clinical onset, but his beta cell function was fairly preserved. Second, it developed during the treatment of type 2 diabetes in an elderly patient.

【 授权许可】

Unknown