Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Immunity & Ageing

Andrea B Maier²  Graham Pawelec¹  Rudi Westendorp GJ²  Ann Vossen CTM³  Evelyna Derhovanessian¹  Yotam Raz²  Anton JM de Craen²  Sijia Chen² 

[1] Tübingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Medical School, Tübingen, Germany;Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, the Netherlands;Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands

关键词: Oldest olds;    Elderly;    C-reactive protein;    Non-fasting glucose;    HbA1c;    Type 2 diabetes;    IgG antibody level;    Seropositivity;    Cytomegalovirus;   

Others  :  817376
DOI  :  10.1186/1742-4933-9-18

 received in 2012-05-28, accepted in 2012-08-08,  发布年份 2012

【 摘 要 】

Background

Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.

Results

CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).

Conclusions

In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

【 授权许可】

   
2012 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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