The beta-chemokines MIP-1alpha and RANTES and lipoprotein metabolism in HIV-infected brazilian patients

Brazilian Journal of Infectious Diseases

Costa, Paulo Inácio da²  Tagliavini, Sandra Antonia¹  Abrão, Emiliana P.¹  Malavazi, Iran¹  Mikawa, Angela Yumico¹ 

[1] São Paulo State University;São Paulo State University, São Paulo, Brazil

关键词: b- chemokine;    HIV;    genotype;    lipoproteins;    cholesterol;    triglyceride.;   

DOI  :  10.1590/S1413-86702005000400008

来源: Contexto

【 摘 要 】

HIV patients are predisposed to the development of hypertriglyceridemia and hypercholesterolemia as a result of both viral infection and HIV infection therapy, especially the protease inhibitors. Chemokines and cytokines are present at sites of inflammation and can influence the nature of the inflammatory response in atherosclerosis. We investigated the correlation between biochemical variables and b-chemokines (MIP-1a and RANTES) and the apolipoprotein E genotype in HIV-infected individuals. The apolipoproteins were measured by nephelometry. Triglycerides and total cholesterol were determined by standard enzymatic procedures. The b-chemokines were detected by ELISA. The genetic category of CCR5 and apolipoprotein E were determined by PCR amplification and restriction enzymes. Immunological and virological profiles were assessed by TCD4+ and TCD8+ lymphocyte counts and viral load quantification. Positive correlations were found between apo E and CD8+ (p = 0.035), apo E and viral load (p = 0.018), MIP-1a and triglycerides (p = 0.039) and MIP-1a and VLDL (p = 0.040). Negative correlations were found between viral load and CD4+ (p = 0.05) and RANTES and CD4+ (p = 0.029). The b-chemokine levels may influence lipid metabolism in HIV-infected individuals.

【 授权许可】

CC BY-NC-ND