Evaluation of Isotonic Sodium Bicarbonate Solution for Alkalizing Effects in Conscious Calves

Journal of Veterinary Medical Science

Ryuji ASANO¹  Kazuyuki SUZUKI¹  Shigehiro IWABUCHI²  Izumi ABE²  Shigehisa TSUMAGARI¹  Tsutomu MATSUMOTO¹ 

[1] Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University;Central Research Laboratories, Nippon Zenyaku Kogyo Co., Ltd

关键词: acid-base equilibrium;    calf;    coefficient of distribution;    metabolic acidosis;    sodium bicarbonate;   

DOI  :  10.1292/jvms.64.699

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(5)After intravenous (IV) infusion of various volumes of 1.35%-isotonic sodium bicarbonate solution (ISB), acid-base equilibrium, blood pressure, plasma volume and biochemical parameters in healthy Holstein calves were studied. Four calves each were randomly assigned to the low-dose (LD; IV infusion of 5 ml/kg ISB), middle-dose (MD; IV infusion of 10 ml/kg ISB) and the high-dose groups (HD; IV infusion of 15 ml/kg ISB). Administration volumes of ISB in the LD, MD and HD groups were decided based on the first half volumes of 5, 10 and 15 mEq of base requirement by the acceptable equation. Systemic, pulmonary artery and central venous pressures, cardiac output and plasma osmotic pressure were not changed by ISB infusion and remained constant throughout the experiment for all groups. There was good correlation (r2 = 0.950) between relative changes in base excess and infused volume of bicarbonate (y=2.491x). The coefficient of distribution for bicarbonate ions was calculated to be 0.401 (=1/2.491). Therefore, it is suggested that a value of 0.4 would be most appropriate when calculating the base requirements in calves. Therefore, the first half volumes of ISB correcting base deficits of 5, 10 and 15 mEq in calves were estimated to be 6, 12 and 18 ml/kg, respectively. On the basis of the findings in this study, ISB may be used to correct metabolic acidosis without altering the plasma osmotic pressure, hemodynamic status and respiratory function in the calves.

【 授权许可】

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