Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]

Endocrine Journal

Minako Imamura¹  Shiro Maeda¹ 

[1] Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama 230-0045, Japan

关键词: Type 2 diabetes;    Genetics;    Genome-wide association studies;    Clinical translation;   

DOI  :  10.1507/endocrj.EJ11-0113

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(80)Cited-By(50)Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed genetic susceptibility variants for type 2 diabetes (T2D).Approximately 40 variants have been identified so far, many of which were discovered through GWAS. This success has led to widespread hope that the findings will translate into improved clinical care for the increasing numbers of patients with diabetes. Potential areas or clinical translation include risk prediction and subsequent disease prevention, pharmacogenetics, and the development of novel therapeutics. However, the genetic loci so far identified account for only a small fraction (approximately 10%) of the overall heritable risk for T2D. Uncovering the missing heritability is essential to the progress of T2D genetic studies and to the translation of genetic information into clinical practice.

【 授权许可】

Unknown