Implementation of fast macromolecular proton fraction mapping on 1.5 and 3 Tesla clinical MRI scanners: preliminary experience

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Yarnykh, V.^1,2 ; Korostyshevskaya, A.^3

Department of Radiology, University of Washington, Seattle

WA, United States^1

Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^2

Institute International Tomography Center, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia^3

关键词: Biophysical parameters;    Clinical application;    Clinical scanners;    Clinical translation;    Magnetic Resonance Imaging (MRI);    Magnetization exchange;    Mapping applications;    Modified pulse sequences;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012010/pdf
DOI  :  10.1088/1742-6596/886/1/012010

学科分类：卫生学

来源: IOP

【 摘 要 】

Macromolecular proton fraction (MPF) is a biophysical parameter describing the amount of macromolecular protons involved into magnetization exchange with water protons in tissues. MPF represents a significant interest as a magnetic resonance imaging (MRI) biomarker of myelin for clinical applications. A recent fast MPF mapping method enabled clinical translation of MPF measurements due to time-efficient acquisition based on the single-point constrained fit algorithm. However, previous MPF mapping applications utilized only 3 Tesla MRI scanners and modified pulse sequences, which are not commonly available. This study aimed to test the feasibility of MPF mapping implementation on a 1.5 Tesla clinical scanner using standard manufacturer's sequences and compare the performance of this method between 1.5 and 3 Tesla scanners. MPF mapping was implemented on 1.5 and 3 Tesla MRI units of one manufacturer with either optimized custom-written or standard product pulse sequences. Whole-brain three-dimensional MPF maps obtained from a single volunteer were compared between field strengths and implementation options. MPF maps demonstrated similar quality at both field strengths. MPF values in segmented brain tissues and specific anatomic regions appeared in close agreement. This experiment demonstrates the feasibility of fast MPF mapping using standard sequences on 1.5 T and 3 T clinical scanners.