Anemia with Chronic Renal Disorder and Disrupted Metabolism of Erythropoietin in ICR-derived Glomerulonephritis (ICGN) Mice

Journal of Veterinary Medical Science

Youhei MIYAMOTO⁴  Naotsugu AKASHI⁴  Noboru MANABE⁴  Misuzu YAMAGUCHI-YAMADA⁴  Yoshie YAMAMOTO¹  Hajime MIYAMOTO⁴  Masaya NAGAO³  Yasufumi GOTO⁴  Atsuo OGURA²  Kozue UCHIO-YAMADA⁴ 

[1] Department of Veterinary Sciences, National Institute of Infectious Diseases;Bioresource Center, RIKEN;Laboratory of Biosignals and Response, Department of Applied Molecular Biology, Kyoto University;Unit of Anatomy and Cell Biology, Department of Animal Sciences, Kyoto University

关键词: erythropoietin (EPO);    hereditary nephrotic ICR-derived glomerulonephritis (ICGN) mouse;    kidney;    liver;    renal anemia;   

DOI  :  10.1292/jvms.66.423

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(29)Cited-By(8)The ICR-derived glomerulonephritis (ICGN) mouse, a new inbred mouse strain with a hereditary nephrotic syndrome, is considered to be a good model of human idiopathic nephrotic syndrome and notably exhibits proteinuria and hypoproteinemia from the neonatal stage. In chronic renal disorder (CRD), anemia is a major subsequent symptom (renal anemia). The precise cause of renal anemia remains unclear, primarily owing to the lack of appropriate spontaneous animal models for CRD. To establish adequate animal models for anemia with CRD, we examined the hematological-biochemical properties and histopathological characteristics. With the deterioration of renal function, ICGN mice developed a normochromic and normocytic anemia, and exhibited normochromic and microcytic at the terminal stage. The expression of erythropoietin (EPO) mRNA both in the kidneys and liver and the EPO leak into the urine were observed in ICGN mice, indicating a disrupted metabolism of EPO in ICGN mice. In addition, a lack of iron induced by the hemolysis in the spleen and the leak of transferrin into urine as proteinuria aggravated the anemic condition. In conclusion, the ICGN mouse is a good model for anemia with CRD.

【 授权许可】

Unknown