Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats

Brazilian Archives of Biology and Technology

Denise Pereira Müzell¹  Adroaldo Lunardelli¹  Carlos Eduardo Leite¹  Rodrigo Medeiros Fagundes¹  Vasyl Custódio Saciura¹  Carlos Luiz Reichel²  Jarbas Rodrigues De Oliveira¹  Leandro Vieira Astarita¹ 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul Laboratório de Anatomia Patológica Porto Alegre RS ,Brasil

关键词: Acetaminophen;    Melissa officinalis;    pleurisy;    anti-inflammatory;    kidney;    liver;   

DOI  :  10.1590/S1516-89132013000300006

来源: SciELO

【 摘 要 】

This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results suggested that the extract was not hepatoprotective and could lead to an increase in the lesions induced by the APAP. On the other hand, the extract was nephroprotective against the lesions induced by the APAP and showed an anti-inflammatory effect on pleurisy carrageenan-induced.

【 授权许可】

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