Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

Molecules

Cristiane B. de Oliveira¹  Lucimara N. Comunello¹  Adroaldo Lunardelli¹  Robson H. Amaral¹  Melissa G. S. Pires¹  Gabriela Lucas da Silva¹  Vanusa Manfredini¹  Carmen Regla Vargas¹  Simone C. B. Gnoatto¹  Jarbas R. de Oliveira¹ 

[1] ¹Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil ²Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil ³Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, UFRGS, Porto Alegre, RS 93050-150, Brazil

关键词: anti-inflammatory;    antioxidant;    Baccharis trimera;    phenolic compounds;    pleurisy;    saponin;    TAR;   

DOI  :  10.3390/molecules17011113

来源: mdpi

【 摘 要 】

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.