Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

Endocrine Journal

Mustafa KUCUK²  Tulay KILIC-OKMAN²  Sibel GULDIKEN¹ 

[1] Department of Endocrinology and Metabolism, Trakya University Faculty of Medicine;Department of Obstetrics and Gynecology, Trakya University Faculty of Medicine

关键词: Homocysteine;    Polycystic ovary syndrome;    Insulin resistance;   

DOI  :  10.1507/endocrj.51.505

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(21)Cited-By(10)Hyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 ± 5.86 years) and twenty-five healthy subjects (age, 25.24 ± 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hcy and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hcy.

【 授权许可】

Unknown