Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

Journal of Pharmacological Sciences

Geng-Ruei Chang¹  Ying-Ying Wu¹  Yi-Shin Chiu¹  Jiunn-Wang Liao²  Wen-Ying Chen¹  Frank Chiahung Mao¹  Te-Hsin Chao¹ 

[1] Department of Veterinary Medicine, National Chung Hsing University, Taiwan;Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taiwan

关键词: rapamycin;    obesity;    food intake;    adipose tissue;    leptin;   

DOI  :  10.1254/jphs.08215FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(51)Cited-By(38)Supplementary materials(2)Rapamycin (RAPA), an immunosuprpressive drug used extensively to prevent graft rejection in transplant patients, has been reported to inhibit adipogenesis in vitro. In this study, we investigated the anti-obesity effects of RAPA in C57BL/6J mice on a high-fat diet (HFD). Mice treated with RAPA (2 mg/kg per week for 16 weeks) had reduced body weight and epididymal fat pads/body weight, reduced daily food efficiency, and lower serum leptin and insulin levels compared with the HFD control mice. However, RAPA-treated mice were hyperphagic, demonstrating an increase in food intake. Dissection of RAPA-treated mice revealed a marked reduction in fatty liver scores, average fat cell size, and percentage of large adipocytes of retroperitoneal and epididymal white adipose tissue (RWAT and EWAT), compared to the HFD control mice. These results suggest that RAPA prevented the effect of the high-fat diet on the rate of accretion in body weight via reducing lipid accumulation, despite greater food intake. It is likely that RAPA may serve as a potential strategy for body weight control and/or anti-obesity therapy.

【 授权许可】

Unknown