Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice

Journal of Pharmacological Sciences

Issei Komuro¹  Masashi Ohtsuka¹ 

[1] Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine

关键词: Na+/Ca2+ exchanger (NCX);    knockout mouse;    heart;    ischemia/reperfusion injury;   

DOI  :  10.1254/jphs.FMJ04002X5

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(21)Cited-By(6)We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.

【 授权许可】

Unknown