HIC2, a new transcription activator of SIRT1

FEBS Letters

article

Ji-Yang Song¹  Seung-Hyun Lee¹  Min-Kyeong Kim¹  Bu-Nam Jeon¹  Su-Yeon Cho¹  Sun-Ho Lee¹  Kyung-Sup Kim¹  Man-Wook Hur¹ 

[1] Brain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Research Institute, Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine

关键词: heart;    HIC1;    HIC2;    ischemia/reperfusion injury;    SIRT1;    transcription;   

DOI  :  10.1002/1873-3468.13456

来源: John Wiley & Sons Ltd.

【 摘 要 】

The protein deacetylase SIRT1 is crucial to numerous physiological processes, such as aging, metabolism, and autoimmunity, and is repressed by various transcription factors, including HIC1. Conversely, we found that HIC2, which is highly homologous to HIC1, is a transcriptional activator of SIRT1 due to opposite activity of the intermediate domains of the two homologs. Importantly, this relationship between HIC2 and SIRT1 could be important for cardiac development, where both proteins are implicated. Here, we assessed whether ectopic expression of HIC2, and subsequent upregulation of SIRT1, might decrease apoptosis in H9c2 cardiomyocytes under simulated ischemia/reperfusion (I/R) injury conditions. Our results demonstrate that unlike its structural homolog HIC1, HIC2 is a pivotal transcriptional activator of SIRT1 and, consequently, may protect the heart from I/R injury.

【 授权许可】

Unknown