Cytopathological observations on renal tubule epithelium cells in common carp Cyprinus carpio under Trypanoplasma borreli (Protozoa: Kinetoplastida) infection

Diseases of Aquatic Organisms

Udo Hetzel¹  Wolfgang Körting¹  Dieter Steinhagen¹  Sabine Rudat¹  Wolfgang Drommer¹ 

关键词: Trypanoplasma borreli;    Blood flagellates;    Cytopathology;    Tubular necrosis;    Cyprinus carpio;   

DOI  :  10.3354/dao040203

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Cytological alterations in renal tubule epithelium cells of carp Cyprinus carpio infected with the blood flagellate Trypanoplasma borreli Laveran & Mesnil, 1901 were investigated during the course of a laboratory infection of ahighly susceptible carp line. With the development of the parasitaemia, a hyperplasia of the interstitial renal tissue was induced, which resulted in a tubulus necrosis. Cytological changes were already seen in tubulus epithelium cells on Day 7 postinjection (PI) of the parasite. The basilar invaginations of the cells fragmented and a swelling of mitochondria was noted. With increasing parasitaemia, on Days 14 and 21 PI, these changes progressed up to the loss of the basilar invagination and highamplitude swellings of mitochondria and deterioration of their internal membrane structures. Cells of the distal tubule segment reacted earlier and more rapidly than cells of the proximal tubule. The cytological alterations suggested a loss of function ofthe epithelum cells, which most likely resulted in impaired ionic and osmotic regulation of T. borreli-infected fishes. Our findings indicate that in response to the proliferation of the interstitial renal tissue cell structures of the renaltubule cells are altered quickly and in a progressive manner.

【 授权许可】

Unknown