Genetic Variation of Envelope gp90 Gene of Equine Infectious Anemia Virus Isolated from an Experimentally Infected Horse

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA²  Xian-Gang KONG³  Yuji KONO¹  Takeo SUGIURA⁴  Hiroshi SENTSUI³  Hai PANG³  Hiroomi AKASHI³ 

[1] Japan International Cooperative Agency, Asean Poultry Disease Research and Training Centre, Veterinary Research Institute;Department of Veterinary Internal Medicine and Molecular Immunology, School of Agriculture and Life Sciences, The University of Tokyo;National Institute of Animal Health;Epizootic Research Station, Equine Research Institute, The Japan Racing Association

关键词: env gp90 gene;    equine infectious anemia virus;    mutation;    nucleotide sequence;   

DOI  :  10.1292/jvms.59.1089

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Cited-By(7)Six strains of equine infectious anemia virus (EIAV) were recovered from febrile and non-febrile stages of a horse experimentally infected with the P337-V70 strain given once to a horse. The env gp90 genes of the isolates, the P337-V70 and P337-V26, avirulent virus derived from the P337-V70 strain, were sequenced. A comparison of the gp90 gene sequences revealed that amino acid variations among the viruses tested showed as high as 8.2 to 11.5%. In addition, the comparison also indicated that the isolates that recovered from the non-febrile stage were contained in nucleotide insertions in the principal neutralizing domain (PND) region. The insertions were arranged regularly with smaller segments. The nucleotide sequence of the P337-V26 gp90 gene was found to contain a six-nucleotides insertion and seven nucleotide substitutions outside the PND region, when compared with that of the P337-V70 strain.

【 授权许可】

Unknown