Use of nuclear medicine and imaging techniques in disorders of the bone system

Revista Cubana de Ortopedia y Traumatología

Hernández Falcón, Daylín²  Marrero Riverón, Luis Oscar¹  Ledea Lozano, Oscar E² 

[1] Complejo Científico Ortopédico Internacional Frank País, La Habana, Cuba;Centro Nacional de Investigaciones Científicas, La Habana, Cuba

关键词: radioisotopes;    radiopharmaceuticals;    diagnosis;    radiotherapy;    bone system;   

DOI  :  

学科分类：生理学

来源: SciELO

【 摘 要 】

Nuclear medicine is the medical specialty that deals with clinical diagnosis, treatment and research through the use of isotopes as open sources. Bone diseases such as osteoporosis, primary bone cancer, bone metastases, arthrosis and arthritis are common among the population. The objective of this review was to present international and national statistics, and evaluate the incidence of these disorders. Additionally, a review was conducted of various clinical studies to identify the radiopharmaceuticals most frequently used to diagnose and treat bone disease, and their combination with the most common imaging techniques. A presentation was made of the usefulness of bone gammagraphy and the confirmation of the disorders studied. Reference was also made to the use of new techniques such as single photon emission tomography or positron emission tomography. It was found that the radioisotope most commonly used to diagnose diseases of the bone system was 99mTc, due to its physical and chemical characteristics, whereas 186Re, 188Re, 153Sm, 177Lu, 32P, 89Sr, 85Sr, 117mSn are used for therapeutic purposes, depending on the type, location and magnitude of the lesions and the availability of the radioisotope. At present, radiopharmaceutical development centers on combining these radioisotopes with various biomolecules to improve their properties and broaden their field of application.

【 授权许可】

Unknown