Technical Report (Final): Development of Solid State Reagents for Preparing Radiolabeled Imaging Agents

Kabalka, George W

关键词: Radiolabeled materials solid state positron tomography synthesis radioisotopes;   

DOI  :  10.2172/1013883
RP-ID  :  DOE/ER/64698-3
PID  :  OSTI ID: 1013883

学科分类：放射科、核医学、医学影像

美国|英语

来源: SciTech Connect

【 摘 要 】

The goal of this research was on the development of new, rapid, and efficient synthetic methods for incorporating short-lived radionuclides into agents of use in measuring dynamic processes. The initial project period (Year 1) was focused on the preparation of stable, solid state precursors that could be used to efficiently incorporate short-lived radioisotopes into small molecules of use in biological applications (environmental, plant, and animal). The investigation included development and evaluation of new methods for preparing carbon-carbon and carbon-halogen bonds for use in constructing the substrates to be radiolabeled. The second phase (Year 2) was focused on developing isotope incorporation techniques using the stable, boronated polymeric precursors. The final phase (Year 3), was focused on the preparation of specific radiolabeled agents and evaluation of their biodistribution using micro-PET and micro-SPECT. In addition, we began the development of a new series of polymeric borane reagents based on polyethylene glycol backbones.