Coexistence of Corticotroph Adenoma and Thyrotroph Hyperplasia in a Dog

Journal of Veterinary Medical Science

Susumu TAKEKOSHI¹  Robert Y. OSAMURA¹  Yasushi HARA³  Yasuji HARADA³  Kae SHIGIHARA³  Takuya YOGO³  Yoshinori NEZU³  Masahiro TAGAWA³  Takahiro TESHIMA³  Akira TERAMOTO² 

[1] Department of Pathology, Tokai University School of Medicine;Department of Neurosurgery, Nippon Medical School;Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University

关键词: canine;    corticotroph adenoma;    Cushing's disease;    pituitary;    thyrotroph hyperplasia;   

DOI  :  10.1292/jvms.71.93

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cited-By(5)Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia.

【 授权许可】

Unknown