Efficacy of Transsphenoidal Surgery on Endocrinological Status and Serum Chemistry Parameters in Dogs with Cushing's Disease

Journal of Veterinary Medical Science

Yasushi HARA²  Yasuji HARADA²  Hirokazu ISHINO²  Hiroyuki MASUDA²  Takuya YOGO²  Yoshinori NEZU²  Masahiro TAGAWA²  Takahiro TESHIMA²  Takahiro TAODA³  Akira TERAMOTO¹ 

[1] Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University;Department of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University

关键词: canine;    Cushing's disease;    hypophysectomy;    transsphenoidal surgery (TSS);    pituitary tumor;   

DOI  :  10.1292/jvms.09-0367

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(53)Cited-By(4)Postoperative changes in endocrinological status and serum chemistry during the 4 years after transsphenoidal surgery (TSS) in 25 dogs with Cushing's disease were investigated in a prospective study. In all 25 dogs, Cushing's disease was diagnosed from resected pituitary tissues as a corticotroph adenoma in the anterior lobe of the pituitary. Prior to TSS, all 25 dogs showed hypercortisolemia. After TSS, the ACTH stimulation test showed continued low serum cortisol concentrations in 21 dogs (84%). In addition, the serum thyroid stimulating hormone concentrations decreased sequentially, while the serum T4 concentrations tended to increase due to the postoperative hormone substitution therapy utilized to avoid secondary hypothyroidism. In regard to serum chemistry, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and total cholesterol are commonly increased in canine Cushing's disease. In this study, ALP, ALT and total cholesterol were increased in 23 cases (92%), 19 cases (76%) and 20 cases (80%), respectively. However, postoperatively, these concentrations gradually decreased. The postoperative serum concentrations of ALP at 1 year, that of ALT at six months to 2 years and that of total cholesterol over the course of the 4 years decreased significantly compared with the concentrations before TSS. These results show that TSS is an effective treatment for canine Cushing's disease and for long-term improvement of hypercortisolemia. Moreover, TSS is effective in improvement of hypercortisolism, such as increased concentrations of serum ALP, ALT and total cholesterol.

【 授权许可】

Unknown