Preclinical validation of the analgesic and anti-inflammatory activity of decoction of fresh aerial parts of Phania matricaroides (Spreng.) Griseb.

Revista Cubana de Plantas Medicinales

García Hernández, Ana Ibis¹  Martínez Guerra, María J¹  Boucourt Rodríguez, Elisa¹  López Barreiro, Marisol¹  Amador, María del Carmen Victoria¹  Morón Rodríguez, Francisco¹  Frías Vázquez, Ana Iris²  Morejón Rodríguez, Zulema¹  Cabrera Suárez, Hirán¹ 

[1] Laboratorio Central de Farmacología, La Habana, Cuba;Universidad de La Habana, La Habana, Cuba

关键词: Phania matricarioides;    manzanilla de la tierra;    anti-inflammatory;    analgesic;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: Phania matricarioides (Spreng.) Griseb (manzanilla de la tierra) is a plant that can be found throughout Cuba and is grown in gardens. The decoction or infusion from the fresh aerial parts is traditionally used to treat digestive and dermatologic problems. However, there was no published study on this species or genre in PubMed, LILACS, NAPRALERT AND CUMED databases. Objective: to evaluate the preclinical analgesic and anti-inflammatory action of the decoction of fresh aerial parts of Phania matricarioides. Methods: the fresh aerial parts of Phania matricarioides were picked up to make decoction. Several pharmacological studies on the 0.75 % acetic acid-induced contortions (0.1 mL/10 g, intraperitoneally administered); tail immersed in water at 55 oC in mice, being the dose of 1 and 5 g of vegetal material/kg of body weight; Croton oil-induced ear edema, orally (0.1 and 1 g/l g) and topically (20 mL/10 g of decoction at 10, 30 and 50 % concentrations) in mice, and finally cotton-induced granuloma in rats. Results: the decoction significantly inhibited the painful response induced by acetic acid, depending on dose (5 g/kg), but did not affect either the tail withdrawal in immersion or the inflammatory response to cotton-induced granuloma; the inflammation treated orally and topically was inhibited in the ear edema. Conclusions: the results allowed performing the preclinical validation of the analgesic and anti-inflammatory action of the decoction of fresh aerial parts of the plant in digestive and dermatological diseases.

【 授权许可】

Unknown