Anti-inflammatory and analgesic activity of an organic extract from the red alga Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux

Revista Cubana de Plantas Medicinales

Cabrera Suárez, Hirán Ramón¹  Martínez Hormaza, Ioanna¹  Ramentol, Rosa Mary³  Suárez Alfonso,³  Morón Rodríguez, Francisco José¹  Frías Vázquez, Ana Iris³  García Delgado, Neivys²  Duménigo González, Abel¹ 

[1] Universidad de Ciencias Médicas de La Habana, La Habana, Cuba;Universidad Nacional Autónoma de México, Ciudad de México, México;Universidad de La Habana, La Habana, Cuba

关键词: Galaxaura rugosa;    anti-inflammatory;    analgesic;    dichloromethane extract;    phytochemical composition;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction:the red alga Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux (Galaxauraceae) is one of the most abundant species on the rocky platform of the Cuban coral reef. However, little is known about its pharmacological properties. Objectives:evaluate the anti-inflammatory and analgesic activity of a dichloromethane extract from the red alga G. rugosa and determine the phytochemical composition of the species. Methods: the algae were collected from the northern coast of Havana. Phytochemical characterization of the alga was performed using Chabra's method. The extract was obtained with a Soxhlet device with dichloromethane at 40 ºC. Topical anti-inflammatory activity was studied with the croton oil ear edema test model in male OF-1 mice at doses of 10*10-3, 0.125, 0.25, 0.5, 1 and 2 mg/ear. The analgesic activity of the extract was evaluated on a model of writhing induced by 0.8 % acetic acid administered intraperitoneally (i.p.) at doses of 3, 6, 12.5, 25 and 100 mg/kg. Results:phytochemical analysis of G. rugosa revealed the presence of fatty, lactonic, triterpenic and/or steroidal compounds, as well as carbohydrates. The dichloromethane extract of G. rugosa at the dose of 0.125 mg/ear displayed a potent anti-inflammatory activity (above 40 %). The extract reduced writhing by more than 75 % with a dose of 6 mg/kg. Conclusions:results show that dichloromethane extract of the red alga G. rugosa is composed of a mixture of compounds capable of inhibiting the acute inflammatory response and the pain induced by chemical agents with a high pharmacological efficacy.

【 授权许可】

Unknown