Persorption of Bovine Lactoferrin from the Intestinal Lumen into the Systemic Circulation via the Portal Vein and the Mesenteric Lymphatics in Growing Pigs

Journal of Veterinary Medical Science

Etsumori HARADA³  Yumiko YOSHIZAWA²  Takashi TAKEUCHI³  Mohammad J. R. TALUKDER³  Kunio ANDO⁴  Hirohiko SHIMIZU⁴  Hiroshi KITAGAWA¹  Toshifumi YOKOYAMA¹ 

[1] Department of Life Science, Graduate School of Science and Technology, Kobe University;Department of Functional Morphology, Faculty of Agriculture, Kobe University;Department of Veterinary Physiology, Faculty of Agriculture, Tottori University;Nuclear Receptor Ligand Co. Ltd.

关键词: bovine lactoferrin;    enzyme-linked immunosorbent assay;    intestine;    persorption;    swine;   

DOI  :  10.1292/jvms.65.567

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(13)The absorption and the transportation of intestinally administrated bovine lactoferrin (LF) were immunohistochemically and physiochemically investigated in the small intestine of growing pigs. At the apical halves of the small intestinal villi, bovine LF was absorbed by transcytosis as small vesicles through villous columnar epithelial cells. The presence of bovine LF-positive membranes of transcytotic vesicles suggests that the absorption was mediated by LF-binding factors on the epithelial cell membranes. Almost all of the absorbed bovine LF was demonstrated to be transported via the lymphatics and the portal vein into the systemic circulation. The LF-concentration in systemic circulation was significantly higher at 1 hr following intestinal administration of bovine LF. Bovine LF-positive lymphocytes also were transferred into the systemic circulation from intestine via the lymphatics and the portal vein.

【 授权许可】

Unknown