Histoplanimetrical Study on the Relationship between the Cell Kinetics of Villous Columnar Epithelial Cells and the Proliferation of Indigenous Bacteria in Rat Small Intestine

Journal of Veterinary Medical Science

Tetsurou INAMOTO²  Yuh YOKOO¹  Hidenori MIYATA¹  Kenkichi YAMAMOTO²  Wang-Mei QI²  Junichi KAWANO¹  Nobuhiko HOSHI¹  Kankanam Gamage Sanath UDAYANGA¹  Hiroshi KITAGAWA¹  Toshifumi YOKOYAMA¹ 

[1] Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University;Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University

关键词: apotosis;    enteric bacteria;    gastrointestinal tract;    host defence;    immuno-histochemistry;   

DOI  :  10.1292/jvms.71.463

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(42)Cited-By(10)The relationship between the kinetics of villous columnar epithelial cells and the expansion of colonies of indigenous bacteria from the narrow apical portions of intestinal villi was immunohistochemically and histoplanimetrically investigated in the small intestine of bromodeoxyuridine administred Wistar rats. As a result, the lifespan of villous columnar epithelial cells was slightly shorter in the distal ileum than in other portions of small intestine, accompanying the minimum height of the intestinal villi of the distal ileum in the small intestine. The migration speed of villous columnar epithelial cells was significantly decreased toward the distal small intestine. The migration speed in the distal ileum was about one-fourth of that in the duodenum. The migration speed of the villous columnar epithelial cells was greater and their lifespans were shorter in the sites with wide expansion of the indigenous bacterial colony from the narrow apical portions of the intestinal villi than that in sites with no or less expansion. Additionally, the expansion of the indigenous bacterial colony from narrow villous apices also immediately shortened the heights of the intestinal villi. These findings suggest that the migration speed of villous columnar epithelial cells might contribute to the regulation of the settlement of bacteria at the villous apices and the inevitable proliferation of indigenous bacteria at the intervillous spaces in the rat small intestine.

【 授权许可】

Unknown