Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif

Viruses

Stefán R. Jónsson¹ 

[1] Institute for Experimental Pathology, University of Iceland, Keldur, 112 Reykjavik, Iceland; E-Mail

关键词: small ruminant lentivirus;    maedi-visna virus;    APOBEC3;    Vif;    restriction factors;    host defence;   

DOI  :  10.3390/v5081934

来源: mdpi

【 摘 要 】

It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.