Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks

Journal of Veterinary Medical Science

Mitsuhiro Furuse¹  Kazutaka Shigemi¹  Sachiko Katayama¹  Mark A. Cline² 

[1] Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University;Department of Biology, Radford University

关键词: arousal;    chick;    clorgyline;    monoamine oxidase-A;    orexin-A;   

DOI  :  10.1292/jvms.10-0358

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)We previously demonstrated that intracerebroventricular (ICV) injection of orexin-A induces arousal and increased metabolic turnover rates of norepinephrine, dopamine, and serotonin in layer (egg-type) chicks. Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and examined behavior of chicks. Behaviors associated with arousal were attenuated in the group of chicks that received clorgyline and orexin-A compared with those that received orexin-A alone. For the monoamine turnover rate, enhancement of the turnover rate of serotonin by orexin-A was attenuated by clorgyline. Therefore, we conclude that orexin-A-induced arousal is dependent upon monoamine neural activities stimulated by MAO-A in chicks.

【 授权许可】

Unknown